Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation

J Med Chem. 1987 Apr;30(4):489-91. doi: 10.1021/jm00387a001.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Alkylation
  • Chemical Phenomena
  • Chemistry
  • Endopeptidases
  • Humans
  • Leukocytes / enzymology
  • Oxazines / chemical synthesis*
  • Oxazines / pharmacology
  • Pancreatic Elastase / antagonists & inhibitors
  • Protease Inhibitors*
  • Serine Endopeptidases
  • Structure-Activity Relationship
  • Substrate Specificity

Substances

  • Oxazines
  • Protease Inhibitors
  • Endopeptidases
  • Serine Endopeptidases
  • Pancreatic Elastase